There is neither complete information concerning type 1 diabetes-specific determinants of vascular damage and their interrelationships nor the minimal time of exposure required for a preclinical cardiovascular alteration.
For both agents, we have analyzed (i) the minimal exposure time required to produce a maximal and dose-related effect on intracellular GSH without altering hepatocyte viability or subsequent survival in culture, and (ii) the relative stability of the GSH levels achieved after removal of both modulators from the culture medium.
In order to determine the minimal exposure time required by CNF1 to exert its effects, cells were treated with CNF1 (18 nM) for different times (ranging from 1 up to 16 hours).
Future studies are needed to further define the minimal level of F-ara-A exposure required for stem cell engraftment so that toxicity is minimized.
In vitro study has shown that human normal osteoblast cell required minimal exposure time to MF exposure to increase cell proliferation [ 39].
This is a result of the elimination of stray light effects present when multiple sequences are synthesized simultaneously as well as by the intrinsically low rate of depurination and other side reactions in the MAS chemistry, which does not use acidic conditions and requires minimal exposure to oxidants.
In the absence of well-conducted, prospective, clinical trials addressing the therapeutic benefit of currently recommended PD targets, 100% f T>MIC could be considered a prudent PD target for beta-lactams in the critically ill; albeit noncritically ill patients may only require minimal exposures of 40-70% f T>MIC.
In the absence of well-conducted, prospective, clinical trials addressing the therapeutic benefit of currently recommended PD targets, 100% fT>MIC could be considered a prudent PD target for beta-lactams in the critically ill; albeit noncritically ill patients may only require minimal exposures of 40-70% fT>MIC.
However, with concerns about sun exposure, committee assumed conditions of minimal exposure to sunlight to describe relationship between intake and serum 25(OH D levels; therefore, it requires adjustment of values to populations exposure to sun.
29 If application of RIT is considered in a clinical setting, where surgery-related complications could require intensive care for the patient, special care should be taken to ensure minimal exposure of medical personnel to radiation.
