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Manmade protein design is founded on the concept that a protein with minimal evolutionary complexity is a viable scaffold for incorporating simple engineering elements responsible for function in natural proteins and enzymes.
Importantly, the model requires not merely that the same bacterial species be present in different adult lizards, but specifically the same strain, with minimal evolutionary divergence (reflecting a recent common demographic history).
Molecular quasispecies are minimal evolutionary units able to evolve coherently and to adapt to environmental changes sufficiently fast to ensure survival.
Interestingly, despite the minimal evolutionary distance among the pseudogenes found in clade 4, these mutations all appear to have originated independently by unique frameshift mutations.
Moreover, much of an organism's protein coding genes are lowly expressed and thus minimal evolutionary pressure has been present to drive efficient natural evolution and optimization [ 11, 28].
In some respects, the C domain alone or in combination with the T domain can be considered the minimal evolutionary unit for NRPSs, as T-C units clearly occur in the absence of A domains.
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The authors state minimal documentation and evolutionary requirements as examples of agile practices that are not suitable for mission and life-critical systems [19].
For those pairs with different localizations, we calculated the minimal number of evolutionary changes (i.e., gains or losses of localizations) required to explain their distinct localizations.
Throughout the New Synthesis, hybridization in animals was relegated to a minimal role in evolutionary theory e.g. [ 1], often only considered important for reinforcing reproductive isolation through the reduced fitness of hybrid offspring [ 2].
But so far at least, "the accomplishments have been minimal," said Francisco Alaya, an evolutionary biologist at the University of California, Irvine.
For each set 25 simulations are run with the shortest evolutionary target (minimal coding length = 13).
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