Sentence examples for minimal efficacious dose from inspiring English sources

This study thus shows that the intraorgan targeting of drugs through cell type-specific delivery holds substantial promise towards lowering the minimal efficacious dose administered systemically.

Conclusion(s): In postmenopausal women with uterine leiomyomas, it is necessary to use the minimal efficacious dose of progestin during HRT because of a higher risk to increase the tumors dimensions.

20 Optimising adalimumab combination therapy to achieve disease control should identify the minimal efficacious dose of MTX in combination with adalimumab.

at ascending doses of 3, 9 and 27 nmol/kg/h (doses were selected based on a pilot study determining a minimal efficacious dose).

An in vivo selectivity of >65 for ELN475516 based on either dose or terminal plasma levels of compound is estimated, where minimal efficacious dose is defined as ≥25% Aβ reduction in the brain at study termination (that is, three hours post last dose), and the minimum toxic dose is defined as the dose producing a statistically significant elevation of Math1 mRNA levels.

If minimum efficacious dose of ruxolitinib cannot be maintained, then consider alternative therapy, including other JAK inhibitors.

The minimum efficacious dose is 160 mg day−1 (level of evidence: B1).

For this study, a minimum efficacious dose was defined as that dose effecting >25% reduction at study termination (that is, three hours post last dose).

The two chemicals have similar potency and efficacy, and the same most efficacious dose around 10 9 to 10 8 M.

However, this differentiation diminishes at the maximum efficacious dose.

Such a disconnect makes predicting PK/PD and efficacious dose in humans very difficult.