*MEC, minimal effective concentration; ND, not determined.
What is the minimal effective concentration, EC50, maximum effect level?
This study thus shows that the intraorgan targeting of drugs through cell type-specific delivery holds substantial promise towards lowering the minimal efficacious dose administered systemically.
20 Optimising adalimumab combination therapy to achieve disease control should identify the minimal efficacious dose of MTX in combination with adalimumab.
at ascending doses of 3, 9 and 27 nmol/kg/h (doses were selected based on a pilot study determining a minimal efficacious dose).
The plasma concentrations in the phase 1 trials exceeded the "efficacious" concentration (IC50) in the in vitro models (1 µmol/L).
Efficacious concentrations of this compound are also well tolerated by mice, making it an attractive prospect for clinical use [ 97].
This may further suggest the utility of BW-based dose when the efficacious concentrations completely saturate the targets.
Further clinical trials are needed to examine the safest and most efficacious concentrations of the various agents, particularly hypertonic saline.
Minimal PARP cleavage was seen in wild-type cells exposed to 1NM-PP1 or AP20187, indicating that these small molecules did not trigger cell death at bio-efficacious concentrations (Fig. S2).
