Sentence examples for minimal efficacious from inspiring English sources
This study thus shows that the intraorgan targeting of drugs through cell type-specific delivery holds substantial promise towards lowering the minimal efficacious dose administered systemically.
Conclusion(s): In postmenopausal women with uterine leiomyomas, it is necessary to use the minimal efficacious dose of progestin during HRT because of a higher risk to increase the tumors dimensions.
20 Optimising adalimumab combination therapy to achieve disease control should identify the minimal efficacious dose of MTX in combination with adalimumab.
at ascending doses of 3, 9 and 27 nmol/kg/h (doses were selected based on a pilot study determining a minimal efficacious dose).
This approach provides a quantitative framework to benchmark biomarker readout against TGI; the potency of crizotinib was captured as the minimal efficacious concentration for 50% of full effect (EC50) on TGI.
An in vivo selectivity of >65 for ELN475516 based on either dose or terminal plasma levels of compound is estimated, where minimal efficacious dose is defined as ≥25% Aβ reduction in the brain at study termination (that is, three hours post last dose), and the minimum toxic dose is defined as the dose producing a statistically significant elevation of Math1 mRNA levels.
The formal evidence for levetiracetam monotherapy in children is minimal: it is potentially efficacious or effective as initial monotherapy in children with benign epilepsy with centrotemporal spikes.
In addition, minimal dark toxicity and efficacious photo-toxicity in vitro were also evaluated by MTT assay.
In conclusion, telephone-based guided self-help is an acceptable minimal intervention which is efficacious in reducing fatigue in adolescents with CFS.
If the self-help booklets are efficacious, this minimal, low cost intervention can be widely disseminated and, hence, has the potential for significant public health impact with respect to reduction in smoking-related illness and mortality.
Posterolateral visualization directly with the camera and via the anterolateral portal is efficient and associated with minimal morbidity but was not efficacious in the cohort evaluated.Level of Evidence:Level II.
