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Both macrocycles 1 and 6 strongly stabilized G-quadruplexes and had minimal effects with duplex DNA, thus confirming earlier results on the stabilization of H-telo by 1.[ 29] The sp center of 6 appeared not to be an impediment.
It is also possible that gamma secretase modulation is best initiated before any plaque deposition has occurred (for example, in patients at risk of AD) and therefore would exert minimal effects with significant amyloid burden as is common in symptomatic AD.
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The evidence indicates that both these once-daily dihydropyridine CCBs lower blood pressure effectively with minimal effects on heart rate.
Etretinate inhibited growth of a murine melanoma but only minimal effects were recorded with two human melanomas.
Shot with minimal effects and usually from the front with one camera, the style and format brings each individual actor's talent to the fore.
A reduction of effective dose up to 70% has been achieved with minimal effects on lung quantitative results.
A reduction of effective dose up to 70% can be achieved with minimal effects on lung quantitative results.
The effective dose can be reduced by up to 70% with minimal effects on quantitative results.
In the scale for geomagnetic storms, G1 is considered "minor" with minimal effects on power systems and satellites.
These active compounds induce apoptotic activity in MCF-7 cells with minimal effects on normal peripheral blood cells.
Here, we show that CC-930 inhibits HDM-induced pulmonary fibrosis with minimal effects on inflammation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com