Exact(2)
However, most drugs are absorbed only when their concentration in the blood is above their minimal effective level.
This minimal effective level was sought because subsequent experiments would involve combinations of the agents and it was felt that more effective exposures could blunt the meaningful examination of combining these agents.
Similar(58)
What are the minimal effective concentration, EC50, maximum effect level, and does the effect level off at high exposure?
What is the minimal effective concentration, EC50, maximum effect level?
derived minimal-effect level.
However there was marked variation between individuals and studies; the observed median Cmin were just above the minimal effective concentration and around 50% of patients showed trough levels below inhibitory levels.
Steroids should be tapered more slowly, and with great care, below this level to reduce the risk of overshooting the minimal effective dose for that individual.
However, liver hepcidin mRNA expression and serum hepcidin level decreased proportionally with the dose starting from the minimal effective dose of 0.2 mg/kg/week (Fig. 4a, b).
We recommend the use of the minimal effective dose of inhaled nitric oxide and continuous monitoring of methemoglobin levels especially in cases of anemia or sepsis.
Plasma GH levels dose-dependently increased at 5 min after NMC injection and the minimal effective dose was 1.0 μg/kg.
The definitions of Minimal effective bifurcating dose (MEBD) and Maximum tolerable bifurcating dose (MTBD).
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