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The minimal effective ketamine serum concentration (150 ng/mL) was only achieved in animals that received 25 mg/kg.
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Evaluation of plasmatic concentration following injection of the different doses in rats revealed that the minimal effective plasma concentration of ketamine (approx. 200 ng/mL) was achieved only in a few animals at 25 mg/kg IP, which is the same plasmatic therapeutic concentration needed for treatment of neuropathic pain in humans [ 45].
What is the minimal effective concentration, EC50, maximum effect level?
Ferriss likes to declare that this is the age of the self-experimenter, and his mantra is "minimal effective dose".
*MEC, minimal effective concentration; ND, not determined.
Minimal effective doses should be used since these are as effective as much higher doses.
Duration of intervention, minimal effective dosage, and formulation will need to be determined.
This may be regarded as a further argument to use minimal effective doses of these drugs.
Typically, the minimal effective dose is utilized to limit treatment-associated toxicity.
The minimal effective dose should be determined and regularly re-evaluated (standard, expert agreement).
Unfortunately, the question of the minimal effective THAL dosage is still unresolved.
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