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Estimates of minimal effective gating charges and voltage independent free energy changes were made using a simplified two state gating model [10], [20].
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What is the minimal effective concentration, EC50, maximum effect level?
Ferriss likes to declare that this is the age of the self-experimenter, and his mantra is "minimal effective dose".
Furthermore, it is essential to determine the minimal effective dose and frequency of administration.
The compounds display minimal effective doses in the range 0.3 10 mg/kg.
This is achieved by setting up the threshold as the minimal effective response rate.
*MEC, minimal effective concentration; ND, not determined.
Two gating parameters were calculated from the open probability plots: V0, the voltage required to close half of the channels, and n, the effective gating charge.
Minimal effective doses should be used since these are as effective as much higher doses.
Duration of intervention, minimal effective dosage, and formulation will need to be determined.
This may be regarded as a further argument to use minimal effective doses of these drugs.
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