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However, dose-response experiments revealed that the minimal dose required for the induction of a B cell response was lower with TRIP.I particles compared to the TRIP.NI particles.
The optimized vaccine also fully protected mice against a lethal challenge with mouse-adapted ZEBOV at a dose 100 times lower than the minimal dose required to achieve full protection with the first generation adenovirus vaccine.
These formulas for clearance suggest a method for identifying a minimal dose required for efficacy.
However, there is no study that addresses the minimal dose required to prolong the duration of motor block, sensorial block, and analgesia without increasing adverse effects.
However, comparison of the number of volunteers with oestradiol concentrations below the limits of detection of the assay, 24 h after the last dose of ZD1033, suggested that 1.0 mg was the minimal dose required for maximal suppression of oestradiol.
Since the dose deposited in the nose is largely below the minimal dose required by intranasal inoculation, this would indicate that the preferred site of infection initiation during aerosol inoculation is the lower respiratory tract.
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Inhalational isoflurane was titrated to the minimal doses required to maintain anesthesia, and septic mice required substantially lower doses than controls, but septic mice are likely to be more susceptible to the effects of anesthesia.
To estimate the minimal effective dose required for full protection, we performed a pilot study with Group 1B (n = 2) that received a 50-fold lower HGN194 dose.
These findings are new and suggest that a much higher minimal dose is required for MVA-S to be immunogenic via mucosal vaccination.
In Figure 9, the minimal duration of probiotic dose required to yield a health state is investigated as the initial time of probiotic administration and the probiotic dose levels are varied.
Minimal adjuvant therapy is defined as half of the dose required to be defined as treatment failure.
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