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The minimal dose and time required to completely prevent bacterial growth of the three microorganisms was determined (20 μg/mL for 5 min).
Because normal cells contain only trace amounts of copper, the organic ligands should form far fewer complexes with copper in them, thus exposing the normal cells to a minimal dose and reducing toxicity.
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Many agents also exhibit reduced bioavailability in minimal doses and react to non-target proteins.
To date, several aspects of cervical priming regimens for IUC insertion and removal remain unclear: the minimal dose of misoprostol and the optimal route, and the timing of administration to achieve the necessary degree of cervical softening before placement.
Spinal anesthesia among the neuraxial blocks in obstetric patients needs strict dose calculations because minimal dose changes, complications and side effects arise, providing impetus for this study.
Activation of ERK and Akt by 1,25(OH)2D was transient, required a minimal dose of 10−9 M and could be blocked by actinomycin D and cycloheximide.
Particle therapy (including protons and carbon ions) allows a highly conformal treatment of deep-seated tumours with good accuracy and minimal dose to surrounding tissues, compared to conventional radiotherapy using X-rays.
Phase I study showed that linifanib had a favorable safety profile with minimal dose limiting toxicities (DLTs) and median PFS of 5.7 months [ 59].
The mean uncertainty (difference between maximal and minimal dose considering all the 10 methods) to estimate the cumulated mean dose to the parotid gland (PG) was 4.03 Gy (SD = 2.27 Gy, range: 1.06 8.91 Gy).
Lithium is a preferred moodstabilizer due its renal excretion and minimal dose adjustment in patients with HCV except in patients with shifting fluid balance resulting from decompensated cirrhosis [ 57].
Pilot experiments were performed to choose the reagent concentrations, which were chosen based on the literature as the minimal dose to induce consistent and predictable morphological changes at immunofluorescence.
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