Since the contribution of CD45RA+ naïve T cells to in vitro HIV-specific T cell responses is minimal, terminally differentiated HIV-specific CD8+ effector cells can be distinguished by co-expression of intracellular IFN-γ and surface CD45RA following stimulation with HIV peptides.
MC3T3-E1 preosteoblasts were plated at 2 × 105 cells per 6-cm plate and 4 × 104 cells per well of a 12-well plate and differentiated in Minimal Essential Medium (Invitrogen, Carlsbad, CA) containing 10% FBS (Invitrogen and Cambrex Bioscience/Lonza, Basel.
However, in addition to the suggestion by Koh et al. [12] that separating different b-values may contribute to this, it was shown herein that the differentiated analysis of minimal and maximal ADC values may increase the value of the imaging [34, 35].
Well-differentiated tumours with minimal invasion may be treated by brachytherapy with intravaginal irradiation.
LEGH is a rare lesion of the uterine cervix; it usually occurs in postmenopausal women and has been proposed that LEGH represents pre-cancerous minimal deviation adenocarcinoma (extremely well-differentiated adenocarcinoma), independent of H-HPV infection.
In contrast to the spleen, vector copy numbers in cardiac and skeletal muscle (which are relatively end-differentiated tissues with minimal turnover) remained relatively stable from the 3-week evaluation through the last evaluation at 18 weeks.
Although ESD is a useful method newly developed not only for endoscopic curative resection of EGCs but also for accurate histological diagnosis, the indications for such endoscopic treatment are limited to small, well-differentiated adenocarcinomas with minimal submucosal invasion (Hirasaki et al, 2005; Kato, 2005).
Messenger RNA levels are expressed relative to murine embryo fibroblasts (Mefs), considered to be a null or a typical differentiated cell that has minimal Nanog expression [56].
Sensitive techniques allow early detection of small numbers of these differentiated leukemic cells, called minimal residual disease; these cells eventually causes relapse of the disease [ 4].
Our study shows that the low clinical response rates of highly differentiated liposarcoma correlate to minimal changes in the expression patterns and that only high grade tumors, especially myxoid/roundcell and pleomorphic tumors, respond to doxorubicin on gene expression level.
