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The computed values for SFC and AUC were lower than the minimal detectable values.
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The theoretical dynamic range of TILDA is > 3logs10 with minimal and maximal detectable values of 1.4 and 3185 cells/10 CD4 + T cells, respectively.
A five degree change was utilized as the definition of responder due to the minimal detectable change values produced using the above described measurement technique.
At 48 weeks, a significant rate of change (improvement) over time was observed in the three limits of stability indicators (endpoint execution: 8.30% LOS, P<0.001; movement velocity: 0.86 degrees/second, P<0.001; directional control: 6.79% of 100, P<0.001); all reached a threshold of real change as judged by the minimal detectable change values.
The MDC95 is the minimal detectable change value that falls outside the measurement error of the instrument with 95% probability.
We estimated minimal important difference (MID) and minimal detectable change (MDC) values of CMYMOP using anchor and distribution based approach respectively [ 22].
The minimal detectable change score value at a 95% confidence level were 0.157 for SF6D and 0.429 for EQ5D, and the difference in mean change score values (SD) between them was 0.23 (0.29) and so exceeded the clinical significant change score value for both instruments.
93 The scale is validated in stroke populations, and values for "minimal detectable change" and "clinically important difference" 99 are established.
The SEM was multiplied by 2 and a 95% CI was calculated to determine a value for minimal detectable change (MDC)[ 16].
In order to explore the ability to detect group differences, we ran a sample size analysis for each parameter with the following assumptions: power = 80%, alpha = 5%, minimal detectable difference = 10% of the overall mean value for that particular parameter.
They demonstrated a high ICC value but a relatively low-absolute reliability (minimal detectable change) of 7.7 points.
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