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Nonresponders have only minimal declines in viral titers, while relapsers have robust declines followed by a rebound in titers either during or after therapy.
Treatment failure occurs either by nonresponse (minimal declines in viral titer) or relapse (robust initial responses followed by rebounds of viral titers during or after therapy).
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A minimal decline in selectivity was obtained over MgHZ-360, even when the reaction was tested for the longest time of 400 h.
Generally, the daily DO measurements reveal that the largest most rapid decline occurs in the shallow thermokarst lake, a gradual moderate decline occurs in the deep dune trough lake, and a minimal decline in the deep kettle lake (Fig. 5).
10 12 In Scotland, over a 13-year period leading up to 2008, there had been minimal decline in behavioural CVD risk factors and no substantial change in socioeconomic inequalities.
The study demonstrated a substantial decline from baseline sexual summary score and urinary incontinence score in patients at 2 years after undergoing surgery, but only a mild to moderate decline in sexual score and a minimal decline in urinary incontinence score in patients who received either EBRT alone or brachytherapy alone.
A recent small study with insulin glargine suggests the relative safety and efficacy of this agent in 15 relatively well-controlled patients with type 1 diabetes who fasted for 18 h and experienced a minimal decline in mean plasma glucose from 125 to 93 mg/dl with only two episodes of mild hypoglycemia (29).
Compared to the sole use of the ULN (Table 2, first column), this entailed a significant improvement in specificity and PPV (P value <0.001 for both comparisons), with only minimal decline in sensitivity and NPV (P values 0.25 and 0.19 respectively).
Defining power based on a 25% difference between biomarker-positive and negative groups, rather than on a 25%percentt slowing of the change in the positive group, had a considerable effect on the power of Logical Memory II given the minimal decline, even in biomarker-positive groups.
The national estimate of TFR showed a minimal decline from 5.7 in the periods 2003 and 2008 to 5.5 in 2013.
This is consistent with previous reports of an elimination T1/2 > 20 days for MeHg in adult M. fascicularis (Stinson et al. 1989; Vahter et al. 1994, 1995) and explains the minimal decline (< 20%) in blood Hg concentrations during the weekly intervals between MeHg doses.
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