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Furin cleaves a wide range of proproteins at the consensus sequence Arg-Xaa-Lys/Arg-Arg-↓, and the minimal consensus sequence for Furin is Arg-Xaa-Xaa-Arg-↓.
Other sites that fit the minimal consensus sequence for Cdk substrates, such as Ser14, Ser26/27, Ser47 and Ser545, are only conserved in higher organisms.
Ser540 fits the full consensus sequence for a Cdk substrate (S/T*-P-x-K/R), and Thr530 fits the minimal consensus sequence for a Cdk substrate (S/T*-P) [26] [28].
The minimal consensus sequence for CK2-mediated phosphorylation has been identified as S/T-X-X-Acidic [29], [30], [31] where the +3 acidic residue can be Asp, Glu, pSer [32], [33] or pTyr [34], but apparently not pThr [32], [34].
The NFAT minimal consensus sequence is GGAAA A) or TGGAAAGT.
The flanking regions around the minimal consensus sequence in the PCSK targets are less well examined.
Similar(47)
The presence of ATR/ATM minimal consensus sequences at the C-terminus of WRN are suggestive of a direct relationship between ATR/ATM and WRN.
Both motifs serve as minimal consensus sequences for numerous kinases, including the large families of cell cycle regulated, mitogen-activated protein kinases (MAPKs) and the cyclin-dependent protein kinases (CDKs).
Although formation of the DNA-protein complex was inhibited by an XRE competitor, sequence C did not contain consensus XRE ([T/G]NGCGTG [A/C] [G/C]A; minimal consensus core sequence GCGTG) [ 17], contrary to the expectation.
The minimal consensus ERE sequence is a 13 bp palindromic inverted repeat: 5'-GGTCAnnnTGACC-3' [52,53].
The AP-1 minimal consensus binding sequence is TGASTCA, where S is either a cytosine or guanine.
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