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The authors reported two minimal clusters of amplification that also covered the aforementioned genes.
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Group differences, masked with the appropriate main task effect (mask thresholded at P < 0.05, uncorrected), are reported at an uncorrected individual voxel threshold of P < 0.005 with a minimal cluster extent of five voxels.
Conversely, more activations were induced in nontrained children, including the left precentral sulcus (x, y, z = −42, −3, 42) and the SMA (x, y, z = −6, 0, 57), with a threshold of P < 0.005 (uncorrected) and a minimal cluster size of 10 voxels.
Conversely, more activations were induced in nontrained children, including the left precentral sulcus (x, y, z = −36, −6, 36) and the left middle frontal cortex (x, y, z = −30, 15, 27), with a threshold of P < 0.05 (uncorrected) and a minimal cluster size of 30 voxels.
In the AP addition task, more activations were elicited in abacus-trained children, including the bilateral middle temporal cortices (x, y, z = −51, −33, −3 on the left; x, y, z = 51, −18, −12 on the right) and the left precuneus (x, y, z = −3, −39, 60), with a threshold of P < 0.001 (uncorrected) and a minimal cluster size of 10 voxels.
We used a threshold diameter of 0.5 based on Pearson correlation and a minimal cluster size of 2 members.
While activations in favor of the AP addition task were found in the SMA, bilateral inferior parietal cortices, middle occipital cortex, precentral sulcus, left superior parietal cortex, left precuneus, left cerebellum, right angular and the bilateral thalamus, and striatum, with the threshold of P < 0.001 (FDR corrected) and a minimal cluster size of 30 voxels (Table 2 and Figure 3).
In the EX addition task, more activations were elicited in abacus-trained children, including the medial prefrontal cortex (MPFC), right caudate, right thalamus, right superior temporal cortex, and the right angular gyrus (see Table 3 and Figure 4), with a threshold of P < 0.011 (FDR corrected) and a minimal cluster size of 30 voxels.
Sequence analysis coupled with gene deletion and disruption revealed that the minimal cluster consists of fom1-4, fomA-D.
All regression analyses were carried out with an exploratory uncorrected statistical threshold set at p<0.001 with a minimal cluster size of 10 voxels.
P values were set at 0.05 FDR False Discovery Ratee) corrected for multiple comparisons in a whole brain analysis, which yielded a minimal cluster size of 5 voxels.
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