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Note that for subjects zk and ay, some of the γ-values are close to 1 after normalization; this corresponds to a minimal "cluster" density which is expected to occur even in random samples.
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We found that increasing the proportion of non-bis DNA libraries with bis-DNA libraries led to a minimal decrease in uniquely aligned reads and significantly increased cluster density, suggesting that pooling unrelated samples that have not undergone bisulfite conversion is not only viable but recommended to decrease sequencing costs.
Illumina libraries were quantified by qPCR for optimal cluster density.
Drebrin-only spine densities were determined by subtracting the densities of GluN1+GluA2+drebrin, GluN1-only and GluA2-only clusters from the total drebrin cluster density.
ERK response variability within clusters decreases with increasing cluster density indicating increased intercellular communication ability.
Minimal cluster size was calculated using Monte Carlo simulation program AlphaSim (AFNI).
AVCBMinhop: denotes the average minimal cluster-hop- count for any two clusters in this model.
K modes are faster and efficient than LCC in producing locally minimal clustering results.
This leads to a set of significant minimal clusters, where minimal means that they have no significant internal cluster structure, according to the condition above.
The authors reported two minimal clusters of amplification that also covered the aforementioned genes.
Clusterings always follow the paradigm of intra-cluster density vs. inter-cluster sparsity.
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