However, because of their minimal clinical responses, several mechanisms of immune evasion of tumours have been implicated as issues to improve cancer immunotherapy.
Los Angeles residents (N = 6) showed only minimal clinical or physiological response to O3, while new arrivals (N = 9) showed significant losses in pulmonary function and a tendency toward increased symptoms.
They found that PK parameters were not different between patients with significant tumor burden and those in clinical response or minimal disease, and that after four injections the final serum rituximab concentrations were similar in both situations.
Clinical response, defined as minimal response or greater, was seen in 10 patients (26%), including five patients achieving a partial response and five patients attaining a minimal response.
In a series of ER-positive patients treated with neoadjuvant letrozole, this group also had low clinical response rates and had minimal decrease in proliferation metrics [ 27].
Although several biomarkers associated with angiogenesis measured before treatment have shown to provide prognostic value, and a few biomarkers are pharmacodynamic, there is minimal information on biomarkers that are true surrogates for clinical response to VEGF inhibitors.
Our study shows that the low clinical response rates of highly differentiated liposarcoma correlate to minimal changes in the expression patterns and that only high grade tumors, especially myxoid/roundcell and pleomorphic tumors, respond to doxorubicin on gene expression level.
Clinical response was defined as a ≥ 20% improvement over baseline PANSS1 7 Total score ("minimal clinical improvement". [ 11]).
Following completion of neoadjuvant radiochemotherapy, according to clinical response evaluation, 53 cases showed partial response, 40 showed minimal response and 1 showed no change.
New anti-cancer agents are often tumorstatic rather than tumoricidal and changes in tumor size can be minimal despite effective treatment thus generating a need for novel methods for assessing clinical response besides tumor volume shrinkage.
