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Some types of tissue, such as liver tissue, show minimal cell division or undergo cell division only when injured.
This action of EGF was reported previously for VSMCs [15] and apparently results from EGF-dependent early DNA synthesis, accompanied by minimal cell division for 0 to 4 days, that leads to subsequent cell cycle arrest [19].
To minimize the effect of cell proliferation on the invasion assay, we have confirmed that, in the first 24 hours, BEAS-2B cells undergo minimal cell division and do not show any noticeable difference in cell proliferation between cells expressing AQP5 and cells expressing mock vector (Fig. S1).
Notably, histone H1° was originally found only in tissues with minimal cell division, such as liver, kidney and brain.
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Although these cells progress into S phase (not shown), there is minimal evidence of complete cell division, as is seen after TCR stimulation (Figure 5).
In several cell types, cells have been shown to have a size threshold, in which they need to grow to a minimal cell size before committing to cell division (Turner et al., 2012).
Therefore, sperm in the Parental stage likely range from a minimal of 36 cell divisions to approximately 40 divisions.
To assess the stability of the microporation-based transfection, the time course and the level of EGFP expression were determined over a period of 3 weeks under conditions of restrained cell division (a-minimal essential medium (MEM) containing 2% fetal bovine serum (FBS) and no passaging).
In particular, our results unravel the minimal requirements for localization of the cell division protein FtsZ.
Further mechanism designed to maintain minimal metabolic rate may involve asymmetric cell division.
Aberrant telomerase activation is a common feature of human cancers, where it allows the growth of malignant cells by ensuring maintenance of a minimal functional telomere length that permits cell division (Kim et al, 1994; Hahn et al, 1999; Gonzalez-Suarez et al, 2000).
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