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Previous studies showed minimal brain uptake of PAMAM dendrimers in healthy and tumor-xenograft-bearing animals.
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Brain uptake was minimal, as expected based on experience with other intravenously administered lysosomal enzymes.
As for the two patients who had negligible brain uptake of VGB after the first dose, only Patient 4 still had minimal increase in microdialysate VGB concentration above baseline after the third dose, while Patient 2 showed a typical increase above baseline.
Increased brain uptake and oxidation of acetate in heavy drinkers.
Ligand coated nanoparticles may improve brain uptake of drugs.
The brain uptake of the IgG fusion proteins, 2 3% of injected dose/brain, is comparable to the brain uptake of small molecules.
Various terms were coined to describe this behaviour, among them minimal brain damage and hyperkinesis.
& Pardridge, W. M. Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor.
"Their accuracy increased twice as fast as those who had minimal brain stimulation.
Mishra, M. K. et al. Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest.
The MELAS subgroup showed a significant relationship of whole brain uptake (n=5, r=0.917, *p=0.028) to improvement in Newcastle score.
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