Sentence examples for minimal anticipated from inspiring English sources

Thus we present a method to experimentally determine receptor occupancy that can be taken as one parameter to define the minimal anticipated biological effect level as the basis for calculating safer starting doses for first-in-human clinical trials for products in which a potential risk has been identified.

These investigations provide the essential information required for the selection of a safe starting dose and escalation for FIH trials based on toxicology and pharmacology data and the minimal anticipated biological effect level (MABEL) by integrating all available in vivo and in vitro data.

Therefore, a PKPD-guided approach to determine the minimal anticipated biological effect level (MABEL) has been recommended to provide a more mechanistic rationale for starting dose selection by considering the human predicted PK, PD, and safety.

For the FIH study, a minimal anticipated biological effect level dose was justified based on the projected 10% target saturation as well as a PK-based dose-escalation scheme 25 illustrating the utility of target-mediated drug disposition models to guide early clinical development.

In Scenario 5, we accounted for changes in yield and composition of DDGS but assumed no impact to CGF or CGM because of the comparatively small fraction of materials in the livestock feeding system and the minimal impact anticipated.

For men treated with teratogenic mAbs, condom use to prevent exposure of a potentially pregnant partner is unlikely to be recommended because of the minimal female exposure anticipated following a vaginal dose.

Overall, only minimal risks are anticipated.

Hence, we anticipated minimal influence of using 2003 data on the overall results.

Volumetric strains measured during hydrate dissociation vanish at 2 4 MPa; therefore, minimal volumetric strains are anticipated during gas production at the Mount Elbert well.

As anticipated, only minimal inhibition was observed when the mutated 3′UTR was used, suggesting HIF3A to be a direct target of miR-210-3p miR-210-3p miR-210-3p

Education programmes, including dietary advice, will be standardized across centres as far as possible, but it is anticipated that minimal variability will be found concerning the educational content of programmes currently used at individual centres.