The only significant adverse event observed occurred during the intravenous infusion of RGD-A-TNF in the highest dose cohort (1013 TU), where a single dose-limiting toxicity (DLT) was noted (Dog #1.18; Grade 3 hypersensitivity reaction); this event (nausea, tachycardia, and hypotension) was transient and resolved with minimal supportive care.
We found and resolved one case of such an inconsistency in both minimal and YP media.
4. Using these assumptions we will explore several models to determine linear range and minimal reliable resolved concentration fold change.
The technical advance relates to the optimization of highly functional Bam complex purification and reconstitution, while the conceptual advances relate to defining the minimal factors for autotransporter assembly and resolving key issues such as lack of an energy requirement.
Sometimes the damage is minimal, and getting it resolved won't cost you more than a headache.
Two thresholds based on the sparking voltage for a positive pulse and on the minimal resolved current for a negative pulse were introduced to draw the boundaries for the application of the circuit structures.
This required compliance with initial criteria for measuring evolutionary change and resolving phylogenetic relationships in this clade with minimal genetic anagenesis in ancestral lineages.
In Stage 2, CRC members' statements were collated and emergent themes recorded by two authors (LE and GH), with disagreements – which were minimal in nature – resolved by consensus discussion.
In patients with anterior uveitis, the severity of inflammation ranged from minimal, resolving spontaneously within 24 h, to severe and required topical corticosteroids with or without a cycloplegic agent and, occasionally, hospitalization.
Moreover, there have previously been minimal attempts to resolve this contradiction (or even to distinguish between statistical and functional redundancy), potentially leading readers to perceive this modelling framework as one prone to capturing invalid biology.
