Sentence examples for minimal alteration in from inspiring English sources
Thus, the role of Ctgf expression in fibrosis remains unclear and there is a need for animal models with variable Ctgf expression in which there is minimal alteration in the natural transcriptional regulation to clarify how altered Ctgf expression levels may predispose or change the progression of heart disease and other fibrotic diseases.
Results show that FuGENE 6 Transfection Reagent exhibits very low cytotoxicity, delivers high transfection efficiency and generates few nonspecific side effects with minimal alteration in gene expression.
In preclinical studies done by our group, the class I DAC inhibitor romidepsin induced apoptosis in CLL cells via activation of caspase 3 and caspase 8, with minimal alteration in caspase 9 activity [10].
However, these pathological changes were accompanied by minimal alteration in glomerular structure and concentrations of BUN and plasma creatinine.
In this resource (using a Z threshold value of 2.0) there was minimal alteration in FRS2 or FRS3 expression.
Studies in healthy older adults associate intensive strength training with increased fat-free thigh mass and quadriceps cross-sectional area and decreased percent body fat and thigh subcutaneous fat with minimal alteration in total body weight [ 27- 30].
The large suite of features associated with nocturnal versus diurnal retinas appear to be organized by relatively minimal alterations in retinogenesis.
Astrocytes and microglia are activated with minimal alterations in the CNS, and are considered sensitive markers of brain damage.
Therefore, it was surprising in our model that minimal alterations in ploidy were observed, and there was no clear evidence of gross chromosomal instability.
In contrast, only minimal alterations in transcription-repressive histone modifications (H3K27m3, H3K9m2, H3K9m3, and H4K20m3) were observed in all tissues.
Their analysis revealed marked differences in the microbiota of mice from the independent mouse colonies, but minimal alterations in cohoused littermates.
