Sentence examples for minimal activation of from inspiring English sources

Results suggest that materials falling within the 20<τoa<40dyne/cm surface-energy range should exhibit minimal activation of blood-plasma coagulation through the intrinsic pathway.

If co-occurrence of large, mossy fiber mEPSCs can trigger a SPW, then minimal activation of the projections should have a comparable effect.

In sharp contrast, when introduced into a mixed peripheral blood cell culture LNP-CD4 preferentially induced CD69 expression on CD4+ cells with minimal activation of CD8+ cells (Fig. 4E,F).

During this treatment signalling was inhibited for 12 hours while Alk4* protein was produced in the last 6 hours of this period in TAG1 cells with minimal activation of Smad2/3.

Due to the observation that negative controls can lead to a minimal activation of T cells [15], the threshold of a significant response was defined to be 0.05% of counted T lymphocytes.

Together, these data suggest that BMP-2 preferentially activates the Smad-1/5 pathway in CMT-U309, clone 4 and CMT-U353 H4, clone 12, causing minimal activation of p38.

For example, amino acids 1 48 contain protine-rich as well as cysteine-rich regions that represent a minimal activation domain of HIV-1 Tat required for activation of the HIV-1 promoter region, known as the long terminal repeat (LTR).

We engineered novel tTA and rtTA variants by replacing the potent activation domain, VP16, with three minimal activation domains of about 14 amino acids each, abbreviated as tTA2 and rtTA2-M2 [28].

This phenomenon is having a major impact on modern drug discovery as it offers the potential to design ligands that selectively activate or inhibit the signalling pathways linked to therapeutic effects with minimal activation or blockade of signalling pathways that are linked to the development of adverse on-target effects.

Figure 5a shows that MT2 added to PC12 cells invariably caused phosphorylation of Tyr490, and that Tyr674/675 and Tyr785 underwent minimal activation, while all of them were clearly phosporylated upon exposure to hrNGF.

It was shown that dCas9-VP160 (10 copies of the VP16 minimal activation domain) efficiently activated endogenous genes when targeted by specific sgRNA to the region within 300 bp upstream of the transcriptional start site.