Sentence examples for minimal activation from inspiring English sources

It was shown that dCas9-VP160 (10 copies of the VP16 minimal activation domain) efficiently activated endogenous genes when targeted by specific sgRNA to the region within 300 bp upstream of the transcriptional start site.

Furthermore, we showed that Akt is activated in PTEN−/− cells but not in PTEN+/+, while minimal activation in PTEN+/− cells.

This phenomenon is having a major impact on modern drug discovery as it offers the potential to design ligands that selectively activate or inhibit the signalling pathways linked to therapeutic effects with minimal activation or blockade of signalling pathways that are linked to the development of adverse on-target effects.

The new Ag composite electrode had minimal activation polarization by 750 °C.

We present results on the minimal activation levels required for focus detection.

The few mutations that did affect transcriptional activation altered acidic residues within the minimal activation domain or the heptad leucine repeat region, rather than leucine residues.

Also, DBD number 2 was purchased as a complete protein, but fused at the C-terminal with the nuclear localization signal, the activator domain VP64 (tetrameric repeat of herpes simplex VP16 minimal-activation domain, GRADALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLIN) and the HA-tag.

Our model suggests a crucial difference between the two tumors: while VEGF188 tumors show minimal VEGFR2 activation, even less than that of VEGF120 tumors, VEGF164Δ108-118 tumors instead show even higher VEGFR2 activation than VEGF164 tumors.

Recently, we defined a minimal CRAC activation domain (CAD; residues 342-448) that binds directly to Orai1 to activate the channel.

Minimal NFκB activation was detected under baseline conditions in each of the three cell lines.

Normal platelet factor 4 and β thromboglobulin indicated absent or minimal platelet activation.