Next, we identified change of mind trials: subsets of free choice trials and biasing change trials (which are free choices throughout, but in which one barrier changes difficulty during the delay).
The design of the ACCORD-MIND trial was described elsewhere (13).
Such a hypothesis can only be tested in prospective studies, such as the ongoing ACCORD-MIND trial.
The effect of glucose lowering on cognitive function will be determined by the ongoing ACCORD-MIND trial.
In brief, six of seven ACCORD clinical networks in the U.S. and Canada comprising 52 of 77 sites participated in the ACCORD-MIND trial.
We included T2DM participants with brain MRI from the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial.
In the Memory in Diabetes study of the Action to Control Cardiovascular Risk in Diabetes (ACCORD-MIND) trial, a trend was observed for decelerated cognitive decline in the treatment arm that was subjected to intensified glucose-lowering treatment [ 31].
78– 81 A large randomized controlled trial, the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial, aimed to compare the effects of intensive versus standard glycemic control on cognitive function and brain volume.
Previously published baseline results from the ACCORD-MIND trial have shown that lower levels of baseline cognitive performance are associated with higher levels of HbA1c and diabetes duration (13).
More work is needed to understand the association between control of type 2 diabetes and the brain, a question currently being investigated in the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND) trial (21).
For example, diabetes is associated with cognitive decline and late-onset dementia (6), but the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) trial recently failed to demonstrate a positive impact of intensive glucose control on cognitive function in type 2 diabetic patients (mean age 62.5 ± 5.8 years) (7).
