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During all the experiments in hypoxia, the subjects breathed hypoxic mixture at rest for 10 min before exercising.
At each visit, participants were in the CR Center for 30 60 min before exercising and then seated for ≥ 5 min for blood pressure and electrocardiogram (ECG) recording.
On average our participants consumed their food at least 1.5 h before exercising while other studies showed GI symptoms were only present when eaten within 30 min before exercising.
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Always stretch before exercising.
Urine was collected 5 min before exercise and again 30 min after the end of exercise.
Capillary glucose was checked 60 and 30 min before exercise and immediately prior to exercise to ensure glucose levels ≥5.5 and ≤13.9 mmol/L.
In the current study, we observed greater plasma metformin concentrations 25 min before exercise and 20 min after exercise compared with samples taken at the same times on the rest day (150 and 225 min postdose).
Patients could also choose to eat a snack before exercise, while all patients were given a snack consisting of 20 g carbohydrates if the reference plasma glucose was <7.8 mmol/L 30 min before exercise.
Plasma metformin concentrations were higher on the exercise day compared with the nonexercise day 25 min before exercise (1,897 ± 352 vs. 1,594 ± 363 ng/mL; P = 0.02) and 20 min after exercise (2,230 ± 335 vs. 1,893 ± 323 ng/mL; P = 0.01).
Eat fruit before exercising.
Warm up before exercising.
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