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In vitro investigations were conducted using a normal human osteoblast cell line that mimics the cellular events of the in vivo intramembranous bone formation process.
The present study was designed to establish a novel in vitro model that mimics the cellular network surrounding airways and pulmonary blood vessels, to study the cardiovascular toxic effects of particulate matter (PM).
As observed in Figure 3 the vd-5'UTR/GFP mimics the cellular localization of the OE23/GFP construct that specifically accumulated in the chloroplasts of N. benthamiana cells (right panels) thus confirming that the GFP translated from the chimeric transcript vd-5'UTR/GFP accumulates specifically in this organelle.
These results suggest that the CSEP that mimics the cellular components and spatial configuration of periosteum plays a critical role in vascularization and osteogenesis.
This gradient in cell phenotypes largely mimics the cellular community of the native enthesis and is therefore a promising first step toward the regeneration of tendon-to-bone insertion.
In Drosophila, either general upregulation of JAK/STAT signaling by the hop Tum gain-of-function mutant, or cell-specific activation of JAK/STAT in circulating hemocytes, mimics the cellular immune response to wasp infection [ 14, 15, 17].
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Corresponding computer simulations were run in randomly generated two-dimensional tissues mimicking the cellular architecture of the strands.
In order to mimic the cellular microenvironment synthetically, it is proposed that stimuli-responsiveness needs to be coupled with hierarchical supramolecular assembly of the materials applied.
To overcome these limitations, researchers have developed organs-on-chips – microfluidic devices that can mimic the cellular architecture and physiology more accurately than conventional methods.
In the current study, we use bone marrow (BM)- and adipose (AD -derived stromAD -derived prepare BM-ECM and AD-ECM, which are decellularized after stromalis by the cells, to mimic the cellular niche for each of these tissues.
This strategy utilizes a biomimetic mechanism of phosphoinositide signaling, in which AuNP supported phospholipid membranes are constructed to mimic the cellular membrane substrate, and AuNPs modified with the pleckstrin homology (PH) domain of cytosolic proteins are designed for specific, multivalent recognition of phosphorylated phosphoinositides.
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