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In vitro study using the GSK3β inhibitor SB216763 mimicked the response elicited by chronic Akt activation.
Both micro- and macro-porous pHEMA substrates were predominately elastic in nature with a narrow range of G′ and G″ values that mimicked the response of human skin.
On the other hand, co-administration of AM251, a cannabinoid CB1 receptor antagonist (0.25 1 ng/rat, intra-BLA), with an ineffective dose of scopolamine (0.5 mg/kg, i.p ., significantly impaired memory consolidation and mimicked the response of a higher dose of scopolamine.
When the high-tech fabric was draped around a device that mimicked the response of human skin on a hot day, the temperature of the artificial skin rose by only 0.8 degrees Celsius.
In addition, we interrogated a spectrum of GLP-1 actions to examine whether Boc5 fully mimicked the response to peptidic agonists by activating each of the three modes of antidiabetic effects.
In the corticosteroid datasets, the dynamic response under the acute case mimicked the response predicted by the indirect effect model in which the dynamic showed a time lag before the maximal activity was reached, and a decline as the drug was cleared from the system.
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Further growth studies revealed that the amide bond hydrolysis product, l-homoserine, mimicked the responses of plants to long-chain AHLs.
Adaptating HSEs to study wound reepithelization has demonstrated several key responses including cell proliferation, migration, differentiation, growth factor responsiveness and protein expression that mimic the response to wounding seen in human skin [7].
A homogenized material model was then calibrated to mimic the response of the cell across the range of stress states that were examined.
The first closed loop control experiment has successfully demonstrated that the digital control system can be programmed to mimic the response of the analogue control system.
Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com