Sentence examples for mimicked the phenotype from inspiring English sources
The double mutation of IP3R1/R2 and pharmacologic inhibition of IP3Rs mimicked the phenotype of the AV valve defect that result from the inhibition of calcineurin, and it could be rescued by constitutively active calcineurin.
Sustained expression of either BAF60a or BAF60b mimicked the phenotype induced by antagomirs.
Furthermore, their WNK4 transgenic mice mimicked the phenotype of PHAII model mice.
To determine if Idlr1 knockout mice also exhibited a hearing impairment phenotype that mimicked the phenotype of DFNB42, we measured the ABR hearing thresholds in Ildr1+/− and Ildr1−/− mice at P21.
Dap is predicted to be regulated by multiple miRNAs and expression of a Dap transgene lacking these putative miRNA-binding sites mimicked the phenotype of dcr-1 loss-of-function.
Treatment of KB cells by bafilomycin A1, a known inhibitor of the vacuolar proton pump, mimicked the phenotype seen in KB-CP-r cells with reduced uptake of HRPO, I-EGF, C-carboplatin, and release of TCA precipitable I-EGF.
Indeed, shRNA treated control iPSC-CMs mimicked the phenotypes changes as well as the susceptibility to apoptosis after electrical stimulation as LMNAR225X/WT and LMNAFrameshift/WT iPSC-CMs.
An NPR2 deletion mutant mimicked the phenotypes produced by a GTP-bound Gtr1 mutant with respect to both autophagy and Tor1 localization, suggesting that Npr2-Npr3 reGTPates GTP hydrolysis in Gtr1.
Detailed phenotypic characterization of the TILLING mutants showed that the G194D mutation mimic the phenotype of CmACO1 antisense line [47].
Thus, the down-regulated TCD10 expression in RNAi lines (Fig. 3g) could mimic the phenotype of the tcd10 mutant.
We recently demonstrated that TNALP-deficient (Akp2−/−) mice, which mimic the phenotype of the severe infantile form of HPP, can be treated by intravenous injection of a recombinant adeno-associated virus (rAAV) expressing bone-targeted TNALP with deca-aspartates at the C-terminus (TNALP-D10) driven by the tissue-nonspecific CAG promoter.
