Treatment with catalase (CAT) and NADPH oxidase inhibitor diphenylene iodonium (DPI) mimicked the effect of FC.
Dibutyryl cGMP (db-cGMP), a cGMP analogue, mimicked the effect of SNP and CNP.
Turning on those nerves, Domingos and colleagues report today in Cell, mimicked the effect that increasing leptin does, stimulating fat breakdown.
8-Bromoguanosine-3′,5′-cyclomo-nophosphate (8-Br-cGMP), a membrane permeable cGMP analog, mimicked the effect of CNP but not cANF (a specific NPR-C agonist).
Expression of a dominant negative form of cyclin D1 in the ES cells abrogated the Notch-induced proliferative response, and, conversely, a constitutively active form of cyclin D1 mimicked the effect of Notch on cell proliferation.
8-Br-cGMP mimicked the effect of CNP on Cch-induced muscarinic currents, and the peak holding current was decreased from − 200.66 ± 54.35 pA of control to − 67.35 ± 24.82 pA.
Consistent with this observation, our data also demonstrated that AICAR mimicked the effect of metformin on CYP2B6 suppression, and such repression was partially but concentration-dependently restored by co-treatment with compound C (6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl 6-[4- 2-piperidin-1-yl-ethoxy -phenyl
The cAMP analogue 8-bromo-cAMP mimicked the effect of PGE2 upon Sost transcription.
Thus, preventing the binding of reelin to its lipoprotein receptors mimicked the effect of secretion blockade.
Another set of compounds, such as fenofibrate, mimicked the effect of FAD mutations by increasing Aβ42 production [13], [25].
Further downstream, it entails downregulation of PKA activity since a specific inhibitor of this enzyme mimicked the effect of CB.
