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The modern bioorganic chemistry concerns the design of synthetic molecules that mimic various aspects of enzyme chemistry and to understand their essential roles in biological systems.
In vitro models span from simple aqueous solutions that mimic the lung surface epithelial lining fluid, to cell culture models, to tissue explants and slices, to intact isolated lungs, and finally to artificial models which attempt to mimic various aspects of the tracheobronchial tree.
Drosophila models for SCA 1, SCA 3, MJD, SMBA and DRPLA have been successfully established and mimic various aspects of this group of diseases such as the presence of mutant protein aggregates, progressive neurodegeneration and behavioural abnormalities [2], [3], [4], [5].
No single animal model of arthritis truly represents the human disease, but the models mimic various aspects and can be used as tools to understand particular pathways.
These data comprise STM 14028 samples from different cell culture conditions designed to mimic various aspects of the non-infectious and infectious environments experienced by Salmonella Typhimurium.
There are a number of available animal models for RA that all mimic various aspects of the disease, possibly reflecting disease pathways that operate in different subgroups of RA patients.
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These models are robust in mimicking various aspects of cell population, but fail to examine the effects of cell deformation and morphology on pattern formation and growth processes.
Therefore, miR-21 over-expression mimics various aspects of cellular senescence of endothelial cells.
Genetic mouse models mimicking various aspects of kidney failure are also available, but these are compromised by the need for breeding to create combined backgrounds with other genetically altered mouse strains [ 20].
SHIV more closely mimics the various aspects of human infection.
Based on the identification of specific mutations in the amyloid precursor protein (APP) and the presenilin (PS1 and PS2) genes that are associated with increased amyloid production, various mouse models have been developed that mimic several aspects of AD.
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