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Thus, strategies to target IM-refractory LSC of CML are worth being explored within this context, taking advantage of LSC selection in hypoxia prior to drug administration in vitro to mimic the impact of treatment on cells already adapted to home in hypoxic tissue areas in vivo.

Clinical studies attempting to mimic the impact of the natural CCR5 deletion on HIV-1 infection are ongoing (NCT01252641 and NCT01044654).

These findings concerning the fornix and its diencephalic projections raise the question of how closely does damage to the fornix mimic the impact of selective hippocampal damage.

Therefore, available data provide a rationale for exploring the value of such compounds to mimic the impact of cromolyn on gut permeability and performance of weanling pigs.

Current findings on the impact of selective lateral mammillary body lesions only partially support this conclusion (Vann, 2005) as these selective lesions do not mimic the impact of complete mammillary body damage (Vann & Aggleton, 2003).

By normalizing the baseline-subtracted data for the scan rate (and small deviations over all area due to film loss associated with the thermal desorption of the TrxR from the electrode), it clear that as v is increased from 200 mV/s to 2 V/s (dashed line) to 20 V/s (solid), the data mimic the impact of lowering the temperatures.

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To address these uncertainties, researchers led by climate modeler Claudia Timmreck of the Max-Planck Institute for Meteorology in Hamburg, Germany, created a climate model that they believe more realistically mimics the impact of the Toba eruption.

Cost-effectiveness was further improved by including productivity costs and mimicking the impact of irreversible radiographic progression.

Silencing of RhAG mimicked the impact of low temperature treatments on petal development by significantly increasing petal number through an increased production of petaloid stamens.

In the present study, we have therefore generated mice in which endogenous PI3K-C2β is converted to a kinase-dead protein, thereby mimicking the impact of systemically administered small molecule kinase inhibitors of PI3K-C2β.

These p110αD933A/WT mice have a 50% reduction in p110α activity in all of the tissues where it is expressed [ 28], mimicking the impact of a systemically administered p110α-selective irreversible ATP-competitive inhibitor.

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