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Science has long had success with prosthetic legs, but it is harder to mimic the complexity and dexterity of hands and arms.
The inability to mimic the complexity of the liver using cell lines and regular primary human hepatocyte (PHH) cultures pose significant limitations for studying host/pathogen interactions.
This limits the utility of these systems, as they cannot effectively mimic the complexity of the multicomponent extracellular matrix (ECM).
Furthermore, a multi-lineage cellular growth model of haematopoietic cells is incorporated to mimic the complexity of the BM.
A significant challenge in chemistry is to create synthetic structures that mimic the complexity and function of natural systems.
The collaborative worlds of hugely popular, networked online games like World of Warcraft have evolved entire economies and social systems that mimic the complexity of small nation-states in the real world.
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Porous polymeric scaffolds have been widely employed as analogues of native extracellular matrix to create a living construct that would mimic the complexities of human tissue function in the field of tissue engineering.
A: Right now we're stuck with animal models that don't exactly mimic the complexities of the human brain or even a migraine attack.
We also created brief genomic research scenarios for the questionnaire but recognize that these may not precisely mimic the complexities of real-life encounters.
Moreover, the likelihood that the availability of transcriptional comodulators of the ERs in vitro and in vivo is similar is highly unlikely (Graham et al. 2000), and thus, in vitro models cannot mimic the complexities of whole animal systems with respect to estrogen-dependent processes and responses to EDCs.
A step towards the aforementioned goals is the polymer membrane functionalization through covalent bonding of chemical anchors or insertion of proteins/peptides, to obtain specific properties like recognition, catalytic activity and facilitated diffusion, mimicking the complexity of a biological membrane.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com