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A sequential multiple assignment randomized trial (SMART) is a novel trial design that can test these dynamic treatment regimens and lead to treatment guidelines that more closely mimic practice.
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Although our model did not exactly mimic clinical practice, our model provides sufficient platform to test the potential therapeutic effects of CVVH on patients after refractory CA treated with CPB.
Firstly, although using clinical specimens approach is convenient and mimic daily practice in many ICUs, this study cannot determine the exact date of phenotype switch because cultures were not regularly performed.
They have also been developed to closely mimic clinical practice.
This may not mimic clinical practice as muscle endurance tests are often repeated after several days.
This design was chosen, since we wanted to mimic daily practice as far as possible.
On the other hand, a study by Anderson and co-workers appears to mimic clinical practice more closely [ 18].
As we aimed to mimic clinical practice, there were minor differences between the exact culture protocols of the different hospitals.
Thus, additional study examining steady-state levels in nonfasting subjects would be required to more closely mimic clinical practice.
Studies must be conducted in multiple sites, and there should be an attempt to mimic medical practice settings.
Neither did we assess exactly how long the babies were held in this position, since it would have been difficult to measure this and still mimic clinical practice.
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