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A key element in virtually every mimetic situation is deception by the mimic, perpetrated upon a third party, which mistakes the mimic for the model.
This could explain why estimated MDCK cell permeability could be considered to be a good mimic for the BBB (for non-active transport).
Polyvinyl alcohol (PVA) cryogel was used as a tissue mimic for the coronary vessel, which was incorporated in a custom-built assembly.
In areas lacking a wired backhaul infrastructure, relays are, and will continue to be, deployed to act as picocell base stations to local user equipments (UEs) and to mimic (for the most part) a UE in the view of the macrocell base station.
The two probes are [2′-iodo-4′- 3′′-trifluoromethyldiazirinyl phenoxy]-d-glucopyranoside (TIPDG), a mimic for the phenyl glucopyranoside arbutin which is transported by SGLT1 with a very high affinity, and [(4′-benzoyl)phenoxy]-d-glucopyranoside (BzG), a model compound for phlorizin, the most potent competitive inhibitor of sugar translocation by SGLT1.
Clearly, Cys 458 serves as an excellent mimic for the location of the substrate, l-serine.
Similar(44)
This negative experience may result from an encounter with the model (such as a wasp) or with the mimic (for example, the sabre-toothed blenny).
The advantage of the simple model presented here is that it can easily be modified to mimic, for instance, the interaction of the NP corona with a novel biological fluid or compartment once new data will be available.
Importantly, the position of Cys 458 serves as an excellent mimic for where the natural substrate, l-serine, binds as discussed further below.
In light of the discrepancy, we identify future opportunities for rational design of viral mimics for the efficient delivery of DNA and RNA.
We report the design of iminosugar-based ceramide mimics for the development of new START domain ligands potentially targeting either protein isoforms.
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