Open image in new window Fig. 10 Os odontoideum: sagittal reformatted CT image of the craniocervical junction performed as part of a trauma CT assessment of a young female victim of a fall from height demonstrates a pre-existing os odontoideum (large white arrow) mimicking a type II odontoid process fracture.
It can often be the case where a particular in vitro system cannot address or mimic a specific type of toxicity due to some inherent limitation such as a deficiency or absence of a particular cell type, biochemical pathway or nuclear transcription factor related to a compound's MOA.
Kizis mimicked the Type A type: " 'Oh, my God, what happened?
To simulate these subpopulations, the catalytic rate constant, k cat, of Mek in the model was changed, mimicking a wild-type Mek (Mek w t ) and a mutant Mek (Mek m u t ) that phosphorylate Erk at different rates.
Overall, these findings indicate that infection of C57BL/6 J mice with Schu S4 does not completely mimic an infection with other type A strains.
Likewise, some toxic responses require direct or indirect interactions between the multiple cell types to mimic an in vivo-like response (e.g. acetaminophen- and LPS-induced toxicity) (DeLeve et al., 1997; Kmiec, 2001; Roberts et al., 2007).
Saporta et al. (2012) recently reported in Brain the development of an Mpz R98C 'knock-in' mouse which mimics a form of CMT type 1B (CMT1B).
Diabetes as a consequence of hemochromatosis is characterized by insulin resistance and β-cell destruction (2), and the metabolic phenotype can therefore mimic type 2 diabetes and nonautoimmune type 1 diabetes (3).
Using these patient data, an aggregated dataset is constructed to mimic the type of data that it routinely available.
To support the therapeutic interest of RU, we investigated its effects in a rat model of adjuvant-induced chronic arthritis, well known to mimic Th1 type pathogenic signs of RA [ 28].
