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The story of India's urbanisation – though slower than that of China or many other developing countries – is made up of hundreds of millions of variants on Kumar's story.
Moreover, many drug candidates can be tested because the BioFab platform can build gene libraries of millions of variants that can then be screened for safety and effectiveness.
A lot of work is devoted to the development of analysis techniques that can cope with the millions of variants emerging and combine data from different variants into one analysis [36].
Ultrahigh-throughput screening methods for rapid analysis of millions of variants are therefore increasingly important for investigating sequence-function relationships, searching large metagenomic libraries for interesting activities, and accelerating enzyme evolution in the laboratory.
For example, one set of modules might be made using any of the existing DNA shuffling protocols and might consist of thousands or even millions of variants.
These tests identify millions of variants per patient far beyond what any single organization can curate.
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More recently, genome-wide association studies (GWAS), which agnostically interrogate hundreds of thousands-to-millions of variants across the genome [87], have revealed genomic regions associated with treatment-related leukaemia [88] and with SMNs occurring among HL survivors initially treated with radiotherapy [89], supporting the idea of genetic susceptibility to treatment-related SMNs.
Moreover the consistency of the genotyping method and the variant validation criteria was confirmed by the high repeatability (0.94) of duplicates, and by the substantial increase in the repeatability measures between the 3rd and 5th step of variant validation procedure.
We identified 236 contigs that were highly variable (in the 99th percentile for highest ratio of variants per contig length) and, as expected of quickly evolving genes, few of these (19%) had homology hits in the BlastX searches, but 98% of them had predicted open reading frames (ORF) larger than 30 bp.
William Nordhaus, an economist at Yale University, has calculated that under 30% of the goods and services consumed at the end of the 20th century were variants of the goods and services produced 100 years earlier.
There are lots of variants.
More suggestions(15)
tons of variants
millions of strains
millions of combinations
millions of alternatives
millions of mutants
millions of derivatives
millions of modifications
millions of versions
thousands of variants
millions of mutant
millions of shoes
millions of users
millions of records
millions of refugees
millions of albums
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