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The setup is designed for solid samples in the lowest milligram range and utilizes rapid heating for thermal activation of the analyte.
The evaluation of explosion hazards for solid and liquid samples in the lowest milligram range was carried out by relying on the response of the substances towards thermal activation rather than on their chemical nature.
The human body's content of selenium is believed to be in the 13 20 milligram range.
Although a direct correlation between rabbit and human retina cannot be made, the retinal toxicity of intravitreal bevacizumab in the milligram range is unlikely given the smaller vitreous volume of the rabbit eye compared with human (<2 ml vs 5 mL) and the relatively large dose used in this study (and hence a much higher effective concentration of drug).
However, the concentration required is far higher than circulating IgG levels and therapeutic levels of mAbs (for example, endogenous IgG levels in normal individuals are about 10 mg/mL while therapeutic levels of mAbs are in microgram per milligram range and at these concentrations FcRn is not saturable).
Similar(53)
A similar study, which employed a peptide immunoaffinity enrichment strategy, measured both estrogen receptor (ER) and HER2 in breast cancer tissue and cell lines and demonstrated linear ranges covering approximately 4 orders of magnitude and limits of detection in the low-femtomole per milligram of protein range.
Chlorine dioxide concentrations in the lower milligram per litre range could be measured.
However, it is less sensitive than, for example, DNA damage strains, with detection limits in the milligram per litre range.
Furthermore, the high concentrations of rhBMP-2 used in these studies (in the milligram per milliliter range) strongly indicate that an optimal method is still lacking.
In addition, in these studies, removal of metal oxide NPs was determined using graphite furnace atomic absorption spectroscopy with sensitivities in the milligram per liter range (Zhang et al. 2008).
It should be noted that, albeit the surprisingly high concentrations in the mg/kg (or milligram per kilogram) range in DON-treated wheat, the relative concentration of the DON-sulfates to that of the parent toxin DON (0.7 %) and to the major plant metabolite D3G (0.4 %) is generally low.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com