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Twenty-eight Holstein cows (157 ± 9 d in milk) were enrolled in 2 experimental periods.
Fourteen lactating Holstein cows (parity 2.6 ± 0.3; 117 ± 18 d in milk) were enrolled in 2 experimental periods.
Twelve primiparous and 16 multiparous healthy Holstein cows in mid lactation (143 ± 37 d in milk) were enrolled in this study.
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Out of 651 eligible children contacted, 624 children [312 in intervention (prebiotic and probiotic milk (PP), 312 in control milk (Co)] were enrolled into the trial (Figure 1).
All dairy herds on the island that were enrolled in official milk recording scheme were invited (n = 199) and all agreed to participate.
Twelve cows were enrolled beginning at 5 d in milk and remained on study through 47 d in milk.
A total of 40 infants were enrolled, including 14 human milk-fed and 26 formula-fed infants (Table 1).
Human milk-fed infants who had consumed HM from birth also were enrolled between 56-70 days of age.
For this, 123 primiparous and 226 multiparous cows from 2 farms, averaging (mean ± standard deviation) 163.9 ± 141.9 d in milk, 35.7 ± 11.3 kg of milk/d, and a body condition score of 2.9 ± 0.5, were enrolled in the study.
Eleven subjects were enrolled.
Sixteen patients were enrolled.
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