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One idea (adverted to by van Inwagen frequently and by Howard-Snyder 2009, 27) is that our cognitive faculties evolved in a milieu which may underwrite their reliability in ordinary life but which does not extend outside that domain.
Thus, derangement of the NLR reflects a pro-inflammatory milieu which may contribute to a poor prognosis.
Moreover, pHSP27 can increase monocyte migration towards the bone milieu which may play a pivotal role in pathogenesis of osteoporosis.
This finding suggests that the FTE of BRCA mutation carriers (FTEb) responds differently to the luteal phase milieu, which may contribute to its predisposition to malignant transformation.
The inhibition of ACE2 by autoantibodies may result in reduced physiological levels of the vasoprotective agent Ang 1-7) in the local vascular milieu, which may induce vasculopathies in patients with underlying disease such as CTD.
Free radicals in smoke produce an oxidative milieu, which may promote the formation of disulfide groups in the active site of the enzyme and may also have a disadvantageous impact on PAD.
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In addition, solubility of BAs is increased in acidic milieu such as metabolic acidosis, which may reflect another factor for urinary cast formation and interstitial tubular damage [52].
These were performed in artificial tear fluid (ATF) with various acidities to simulate the acidic microenvironment which may occur in a milieu of chronic ocular inflammation.
Conversely, kidney dysfunction may generate a thrombotic milieu indirectly through electrolyte or acid-base abnormalities, which may alter activities of enzymes involved in coagulation.
Here, we have reproduced and extended our previous data on modulation of Cav2.3 currents by the schistosome SmCavβ subunit (SmCavβ) in a mammalian cell system, which may better approximate the cellular milieu in which these channels are found in situ.
Further experiments will elucidate the signaling pathways that enable (or inhibit) growth on soft substrates, which may help tailor treatments for tumors based on the mechanical milieu in which they thrive.
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