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It has been shown that the uptake of arginine from extracellular milieu is required for the iNOS dependent NO production [7].
In recent years, it has been demonstrated that IL-10, which has traditionally been thought to contribute to the immunosuppressive milieu, is required for efficient immunosurveillance of the initiation and progression of skin tumours.
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In the physiological milieu, a counterbalancing inhibition is required to prevent inappropriate formation of insoluble crystals of calcium salt [ 17, 18].
The acidic milieu in the lamellar bodies is required for the processing of surfactant proteins and packaging of surfactant lipids [26], [27].
In D. dictyostelium, the transport of iron across the phagolysosomal membrane contributes to pH homeostasis, while at the same time depleting the lysosomal milieu from the iron that is required for bacterial growth.
In order to transmit signals with fidelity in the complex milieu of the cell, tight regulation of catalysis is required.
This suggests that prokaryotic Prohibitins might also function as membrane protein quality control, a function that is required especially during osmotic changes and/or other rapid milieu changes.
This high dose is required due to the bacterial biofilm formation and the local milieu at the infection site [5].
Efficient processing and checkpoint activation are not properties of the S-phase milieu per se but rather require active DNA replication, suggesting that collision of replication forks with the DSB is required.
Different cell types are organized specifically within tissues, thus, materials that can effectively direct specific cell lines spatially in a milieu of other proteins and cell types are required to engineer tissues.
Further studies are required to fully define the chemokine milieu that mediates NK cell trafficking during sepsis.
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