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The activation state of the systemic inflammatory milieu has been proposed as a critical regulator of vascular repair after injury.
The acidic gastric milieu has been discussed to play an important role in nitration as nitrous acid was found to be formed exclusively at low pH, having then the ability to nitrate tyrosine residues of ingested proteins [33].
The environmental milieu has been shown to influence macrophages to assume alternate phenotypes.
Principle: Abrupt alteration of an individual's hormonal milieu has been associated with neurocognitive and neurobehavioural impairments.
Uremic milieu has been implicated as a cause of OSA in patients with CKD.
The change in the cytokine milieu has been suggested as a possible mechanism in several cancers including post-menopausal breast cancer [ 75].
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Yet, few of the composers associated with that milieu have been noted for their solo-piano music.
Studies to elucidate the mechanism of tRNA selection from the intracellular milieu have been hampered due to the difficulties in manipulating the endogenous levels of tRNALys,3.
Non-genetic factors of tumor microenvironment/paracrine milieu have been shown to integrate and influence the genetic framework of cancer; therefore we asked if continuous insult from OPG rich microenvironment could drive normal mammary epithelial cells (HMEC) towards tumorigenic.
The problems related to the crowding of the intracellular milieu have been proposed to be greater for eukaryotic cells, not only for the distances an intermediate have to override to reach a given catalytic site, but especially for the presence of a number of physical obstacles, as the cytoskeleton, multi-enzymatic complexes and organelles.
The complexity of such biochemical features of the in vivo milieu have been hindering our understanding of human biology gleaned from in vitro studies; as such, microfluidic in vivo mimetic platforms possess great potential for facilitating better understanding of human biology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com