Similarly for longevity and the mortality parameters determining it, there was no evidence of any differences between stud and dud treatments when measured in a mixed sex milieu (the environment to which the populations are adapted).
Tracking both the core and surface components by AMS presents a new approach for characterizing transformations of CENPs components in biological milieu or environments.
On the other hand, nucleosome positioning required for maintenance of the optimal internal milieu in one environment may be far from optimal in a different environment.
The outer setting was divided into two, the 'external system' (economic, political, and professional milieu) and 'local environment' (circumstances surrounding the organisation(s) including patient, community, network) as it has been suggested the local environment has been lacking emphasis in previous frameworks [ 36, 37 ].
Its scientific origin is rooted in the studies of French physiologist Claude Bernard (1813 78), who made the key observation that complex organisms such as humans go to great lengths to preserve the constancy of what he called the "milieu intérieur" (internal environment).
This concept paralleled the milieu interne (internal environment) notion advanced earlier by Claude Bernard.
These findings build on emerging evidence for altered brain mechanisms of auditory scene analysis and suggest complex dysfunction of network hubs governing the interface of internal milieu and external environment in AD.
For the sake of having a contemporary living milieu, the traditional environment as the common architectural heritage of the Island can be revitalized, besides developing new appropriate architectural solutions in the light of the natural and cultural context.
We propose that enhancers serve as information integration hubs, at which instructions encoded by the genome are read in the context of a specific cellular state, signaling milieu and chromatin environment, allowing for exquisitely precise spatiotemporal control of gene expression during embryogenesis.
Such approaches disregard the effect of the local milieu on tumor environment, thus limiting the correlation between the model and naturally-occurring tumors[2], [3].
While the structural information may not be as relevant as for say cytosolic enzymes due to the acidic and denaturing environment milieu of the lysosomes, the dependence on sequence specificity is unclear.
