Sentence examples for milestone trials from inspiring English sources

Further studies are needed to analyse in detail the impact of "milestone" trials and related drug regulatory actions on real-life prescription behaviour.

In addition to milestone trials [ 2- 4], current published retrospective data from the large Finnish registry showed in a large group of patients a significant reduction of hospital mortality of survivors of out-of-hospital cardiac arrest after implementation of hypothermia [ 5].

In a milestone trial (NSABP B31), asymptomatic decrease in LVEF occurred in 14% of patients, requiring discontinuation of trastuzumab [ 13].

Over the past decade, Chinese investigators have completed several phase 3 trials [ 5– 8] that have greatly changed the clinical practice of treating lung cancer [ 9], including the Iressa Pan-Asia Study (IPASS), which was a milestone trial [ 5].

However, since the milestone trial by the group of Vicenza in 2000 [ 41], a dose of 35 mL/kg per hour has been widely used, with a trend to increased doses in patients with sepsis [ 42].

Over the years, such physicians accumulated knowledge of the milestones, trials and triumphs experienced by their patients: Well it's because they know you, they know what you're like and, you know, it's just like the doctor that saw [my daughter] learning to drive.

6 8 Milestone clinical trials have demonstrated significant efficacy in terms of improving visual acuity (VA) with monthly injections of ranibizumab.

Furthermore, these encouraging results have been confirmed in the milestone clinical trial PROWESS.

Alongside milestone dates trial staff also recorded delay reasons using a coding system created to cover a variety of potential issues across all stages of the site set up process (see online supplementary table S1).

Although an array of targeted therapies have been investigated, recent milestone Phase III clinical trials have demonstrated forerunners sunitinib (multitarget tyrosine kinase inhibitor) and everolimus (mammalian target of rapamycin [mTOR] inhibitor) could significantly improve progression-free survival (PFS).

It also creates confusion Do you focus on increasing revenue or spend on R&D milestones like clinical trials?