In Vancouver, the NXIVM community was celebrating new enrollment milestones, and recruitment in Mexico City was starting to outpace every other centre on the planet.
We base the planned interim analyses on when the recruitment milestones are met.
To meet recruitment milestones and assure sufficient spectrum of disease severity during the 2 recruitment seasons, infants were also enrolled during acute illnesses.
At study initiation, we will develop a site-specific recruitment timeline, which will include milestones and a clear plan to document all successful and unsuccessful recruitment approaches.
For each proband, we collected data for the perinatal period, assessed developmental milestones and recorded phenotypes at the time of recruitment using a standardized nomenclature called the Human Phenotype Ontology (29).
Where sites took over a specified time to reach milestones (>3 months from MREC to Site Specific Information (SSI) submission, >30 days from SSI validation to local R&D approval, or >30 days from local Research and Development (R&D) approval to opening to recruitment), the longest continuous delay during that milestone was identified.
Series 10 winner Mark Wright's digital marketing agency ran a profit of over £800,000 this year and Ricky Martin runs a leading scientific recruitment consultancy about to reach its £10m revenue milestone.
Chief executive Benny Higgins said: "We are making excellent progress towards the launch of our current account next year and the recruitment of these new roles is an important milestone in that process".
Where sites took over a specified time to reach milestones (>3 months from MREC to SSI submission, >30 days from SSI validation to R&D approval, or >30 days from R&D approval to opening to recruitment) the longest continuous delay reason recorded between those two milestone dates was identified.
Jonathan Jones, head of training and recruitment for the project, said the scheme had reached a "huge milestone", adding it means "we are now a major step closer to delivering the many jobs and opportunities the development will offer".
