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We take the MAQC-II multiple myeloma dataset to predict the overall survival milestone outcome (OSMO, 730-day cutoff) and to predict event-free survival milestone outcome (EFSMO, 730-day cutoff).
The endpoints F and G refer to overall survival milestone outcome (OS) and event-free survival milestone outcome (EFS) of multiple myeloma (MM) data set, respectively, whose cutoffs are both set up as 730 (2*365) days.
One sided Wilcoxon rank-sum test was also performed in the same software to detect the significance of the difference between OS (overall survival milestone outcome) times and EFS (event-free survival milestone outcome) times in the unpredictable samples.
The results of predicting the reoperative treatment response of breast cancer and the overall survival milestone outcome of acute myeloma leukemia showed that our models performed better than those reported by the data contributors.
According to the consistency degree score, overall survival milestone outcome of multiple myeloma was proposed to extend from 730 days to 1561 days, which is more consistent with gene expression profile.
When predicting the overall survival milestone outcome of acute myeloma leukemia, the performance of our model with 50 DEGs was similar to that of the 86-probeset model in original analysis.
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In addition, the areas under the ROC curves (AUCs) were also provided for evaluating the performance of the models on the prediction of the survival milestone outcomes of AML patients and the molecular subclasses of high-grade glioblastoma.
"It is a milestone event.
Baer GD, Smith MT, Rowe PJ, Masterton L. Establishing the reliability of mobility milestones as an outcome measure for stroke.
Most research examining birth history (i.e. related birth complications) and developmental milestone achievement follow outcomes for infants at-risk with very specific birth weight categories and gestational age classifications.
"This report is a milestone study, because the outcome will help improve the juvenile justice system," said UNICEF Representative in Afghanistan Catherine Mbengue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com