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If this study can stand the test of time, it will be a milestone discovery in biology.
Dyer asked the clinicians if the 1986 discovery of the gene responsible for retinoblastoma--a milestone discovery in basic research, as it was the first human-disease gene to be cloned--had made a difference in the lives of the patients.
The milestone discovery was presented Wednesday at a conference of the American Astronomical Society in Texas and also published in papers in Nature and the Astrophysical Journal Letters.
In doing so, he discovered an important role for p53 in apoptosis – a milestone discovery that opened up new avenues of research into the origin of cancer.
Sixty years ago, the milestone discovery of the double-helix structure of the DNA molecule opened a door for scientists to uncover the secret of life.
Although the neuropathology of HCHWA-D is clearly distinct from that of AD, this milestone discovery provided the first evidence that the APP gene harbors autosomal-dominant mutations causing dementia.
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They enabled milestone discoveries in pharmacology and biochemistry ranging from the original formulation of the receptor concept, the first isolation and structural analysis of a receptor protein (the nAChR) to the identification, localization, and differentiation of its diverse subtypes and their validation as a target for therapeutic intervention.
Stefan Jentsch, a molecular cell biologist, made numerous milestone discoveries studying the function of ubiquitin and ubiquitin-like proteins.
The milestone discoveries of histone demethylation indicate that epigenetic methylation marks on other macromolecules could be reversed through the same oxidative demthylation pathway.
Milestone discoveries made in T. thermophila are the discovery of dynein motors[ 2], telomeres[ 3], RNA-mediated catalysis[ 4], telomerase[ 5] and the function of histone acetyltransferases in transcription regulation[ 6].
Although there has been a dramatic increase of research into the epigenetics of breast cancer and milestone discoveries have undoubtedly been made, the application of such findings into the clinical setting has been slow.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com