Analysis of the lipid spectrum showed a mild, yet significant, decrease in total cholesterol and low-density lipoprotein cholesterol levels (P < 0.025), more pronounced in group I.
However, Fryer et. al. did not observe changes in pathology, whereas Cao et. al. reported a mild yet significant increase in plaque deposition.
Concomitantly, the PSAPP mouse model of AD, which over-expresses the full-length human APP containing the V717F mutation, also shows aberrant distribution and a mild, yet significant increase in LDLR protein.
Interestingly, despite the beneficial effects of IL-7 on the MSG treatment, IL-7 alone was responsible for a slowly developing (from 60 minutes after glucose administration) state of a mild, yet significant, glucose intolerance (P-7 vs P-P, p<0.05).
Another study by Piga et al. [ 9] showed a high prevalence of mild, yet significant perfusion anomalies in cerebral cortex of HT patients with euthyroidism, however, this was not observed in patients with non-toxic multinodular goitre.
In line with this observation, we detected a mild yet significant elevation of HDAC6 protein level in the hippocampi of APPPS1-21 micomparedred to wild type controls (Fig 4C).
However, KO synapses showed a mild, yet, significant accumulation of apparently free CCVs (Fig 1A G), an observation confirmed by serial sectioning electron microscopy and quantitative morphometric analysis (Fig 1H).
Wild-type cells showed a very mild yet significant increase in CIN after growth under MCR (P = 0.0019), as well as in the presence of ethanol (P < 0.0001) or Tiron (P = 0.0002).
Studies in animals using laboratory-generated model UFPs or ambient UFPs showed that UFPs consistently induced mild yet significant pulmonary inflammatory responses as well as effects in extrapulmonary organs.
A number of studies have shown that lesions in the perirhinal cortex do not affect spatial recognition or spatial navigation tasks [4,6,10] It must be acknowledged however that there are reports of mild, yet significant impairments following perirhinal cortex lesions in task in working memory versions of the the radial arm maze, water maze and object location [33,34].
