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Milder sensitivity to mitomycin-C of cell cultures depleted of MRG15, relative to BRCA2 and PALB2, was also previously described [ 21].
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Granulomatous uveitis is characterized by blurred vision, mild pain, eye tearing, and mild sensitivity to light.
We found that gcn5Δ cells exhibited mild sensitivity to bleomycin (Fig. 3c) consistent with a role for Gcn5 in DSB repair35.
Deletion of SET2 caused sensitivity to the DSB-causing agent phleomycin (an IR-mimic), mild sensitivity to the alkylating agent methyl methane sulphonate (MMS), but no sensitivity to hydroxyurea (replication stress) or UV (nucleotide damage) (Fig. 1a).
As gcn5Δ exhibited mild sensitivity to DNA damage compared with rad51Δ (Fig. 3c), we tested whether Gcn5 functioned redundantly with other HAT complexes to facilitate the DNA damage response.
swi3-E31 had mild defect in recovery from HU, which is consistent with its mild sensitivity to HU (Figure 1).
Mutations in each of the genes cause a mild sensitivity to DNA damage or DNA replication block.
In fact, mre11 nuclease defective mutants show only mild sensitivity to DNA damaging agents and weak resection defects when compared to mre11Δ cells.
In contrast, a null mutant deleted for the S. pombe SUMO ligase Pli1 has little phenotype, apart from a mild sensitivity to the microtubule inhibitor thiabendazole (TBZ) [27].
The C3H/AnL mouse strain is considered to have mild sensitivity to ADR.
We did observe a mild sensitivity to aphidicolin (Supplementary Fig. 5A).
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